Christian de Duve, who discovered lysosomes, wrote the following ode to the complexity of natural science: "As scientists we do not simply read the book of nature. We write it. Even the physicist has had to admit a subjective aspect to his discipline. How much more so the biologist, who deals with a reality of such elusive complexity that only deliberate simplification can cloak it with the appearance of intelligibility. Nevertheless, that is the way our science progresses. But we must accept our concepts for what they are, provisional approximations that are as much fictions of our minds as they are faithful depictions of facts."
What more is there to say?